Scleroderma is a chronic systemic autoimmune disease characterized by fibrosis (or hardening), vascular alterations, and autoantibodies. There are two major forms: Limited systemic sclerosis/scleroderma cutaneous manifestations mainly affect the hands, arms and face. Previously called CREST syndrome in reference to ...Scleroderma
Scleroderma
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In the skin, systemic sclerosis causes hardening and scarring. The skin may appear tight, reddish or scaly. Blood vessels may also be more visible. Where large areas are affected, fat and muscle wastage may weaken limbs and affect appearance. Also, patients report substantial, even severe and...
The overproduction of collagen is thought to result from an autoimmune dysfunction, in which the immune system would start to attack the kinetochore of the chromosomes. This would lead to genetic malfunction of nearby genes. T cells accumulate in the skin; these are thought to secrete cytokines...
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Scleroderma is a chronic systemic autoimmune disease characterized by fibrosis (or hardening), vascular alterations, and autoantibodies. There are two major forms: Limited systemic sclerosis/scleroderma cutaneous manifestations mainly affect the hands, arms and face. Previously called CREST syndrome in reference to ...
Skin symptoms In the skin, systemic sclerosis causes hardening and scarring. The skin may appear tight, reddish or scaly. Blood vessels may also be more visible. Where large areas are affected, fat and muscle wastage may weaken limbs and affect ... The overproduction of collagen is thought to result from an autoimmune dysfunction, in which the immune system would start to attack the kinetochore of the chromosomes. This would lead to genetic malfunction of nearby genes. T cells accumulate in the ...
Diagnosis is by clinical suspicion, presence of autoantibodies (specifically anti-centromere and anti-scl70/anti-topoisomerase antibodies) and occasionally by biopsy. Of the antibodies, 90% have a detectable anti-nuclear antibody. Anti-centromere antibody is more common in the limited form (80-90%) than in the systemic ...
There is no clear obvious cause for scleroderma and systemic sclerosis. Genetic predisposition appears to be limited: genetic concordance is small; still, there often is a familial predisposition for autoimmune disease. Polymorphisms in ”COL1A2” and ”TGF-β1” may influence severity and ...
In medicine, ”systemic” means affecting the whole body, or at least multiple organ systems. It is in contrast with ”topical” or ”local”. *Systemic disease, an illness that affects multiple organs, systems or tissues, or the entire body *Systemic effect, an ...
Because chronic silicosis is slow to develop, signs and symptoms may not appear until years after exposure. Signs and symptoms include: * Dyspnea (shortness of breath) exacerbated by exertion * Cough, often persistent and sometimes severe * Fatigue * Tachypnea ...
Huggins convened a conference on the biocompatibility of dental materials at the University of Colorado at Colorado Springs, with the assistance of a foundation called the Toxic Element Research Foundation that, according to ”Time” magazine, is used by Huggins to ...
Histological It can occur in any fatty tissue (cutaneous or visceral) and is often diagnosed on the basis of a deep skin biopsy, and can be further classified by histological characteristics based on the location of the inflammatory cells (within ...
The cause is unknown, but it may result from either a viral infection or an autoimmune reaction. In the latter case it is a systemic autoimmune disease. Many people diagnosed with dermatomyositis were previously diagnosed with infectious mononucleosis and Epstein-Barr ...
Indications In general, mycophenolate is used for the prevention of organ transplant rejection. Mycophenolate mofetil is indicated for the prevention of organ transplant rejection in adults and renal transplant rejection in children over 2 years; whereas mycophenolate sodium is indicated ...
Low dose methotrexate is used to treat a wide variety of non-cancerous diseases such as rheumatoid arthritis, lupus, scleroderma, psoriasis, asthma, sarcoidosis, primary biliary cirrhosis, polymyositis, and inflammatory bowel disease. Adapted from the Wikipedia article Antifolate, under the G. N. ... * Acute lymphoblastic leukemia * Acute Thrombocytopenic Purpura * ADHD * Atypical pneumonia * Behçet’s disease * Celiac disease or Coeliac disease * Chikungunya * Chronic fatigue syndrome * Chronic prostatitis/chronic pelvic pain syndrome * Coccidioidomycosis * Community-acquired pneumonia * ...
A large number of causes of myocarditis have been identified, but often a cause cannot be found. In Europe and North America, viruses are common culprits. Worldwide, however, the most common cause is Chagas’ disease, an illness endemic to Central ...
Causes of symptoms of mental illness were customarily classified as “organic” or “functional”. Organic conditions are primarily medical or pathophysiological, whereas, functional conditions are primarily psychiatric or psychological. The DSM-IV-TR no longer classifies psychotic disorders as functional or organic. Rather ...Page 1 of 11
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