The outcome of autoimmune activity is determined by several factors, namely: the intensity, the location, and the duration of the autoimmune response. For an autoimmune response to be beneficial, its intensity, duration and site of activity must be tightly regulated. ...Autoimmunity
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Several mechanisms are thought to be operative in the pathogenesis of autoimmune diseases, against a backdrop of genetic predisposition and environmental modulation. It is beyond the scope of this article to discuss each of these mechanisms exhaustively, but a summary of some of the important...
Autoimmunity is the failure of an organism to recognize its own constituent parts as ''self'', which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Prominent examples include Coeliac...
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The outcome of autoimmune activity is determined by several factors, namely: the intensity, the location, and the duration of the autoimmune response. For an autoimmune response to be beneficial, its intensity, duration and site of activity must be tightly regulated. ...
Several mechanisms are thought to be operative in the pathogenesis of autoimmune diseases, against a backdrop of genetic predisposition and environmental modulation. It is beyond the scope of this article to discuss each of these mechanisms exhaustively, but a summary ...
While a high level of autoimmunity is unhealthy, a low level of autoimmunity may actually be beneficial. First, low-level autoimmunity might aid in the recognition of neoplastic cells by CD8+ T cells, and thus reduce the incidence of cancer. Second, ...
Autoimmunity is the failure of an organism to recognize its own constituent parts as ”self”, which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune ...
A person’s sex also seems to have some role in the development of autoimmunity, classifying most autoimmune diseases as ”sex-related diseases”. Nearly 75% of the more than 23.5 million Americans who suffer from autoimmune disease are women, although it is ...
An interesting inverse relationship exists between infectious diseases and autoimmune diseases. In areas where multiple infectious diseases are endemic, autoimmune diseases are quite rarely seen. The reverse, to some extent, seems to hold true. The hygiene hypothesis attributes these correlations ...
Diagnosis of autoimmune disorders largely rests on accurate history and physical examination of the patient, and high index of suspicion against a backdrop of certain abnormalities in routine laboratory tests (example, elevated C-reactive protein). In several systemic disorders, serological assays ...
Protective autoimmunity is a condition in which cells of the adaptive immune system contribute to maintenance of the functional integrity of a tissue, or facilitate its repair following an insult. The term ‘protective autoimmunity’ was coined by Prof. Michal Schwartz ...
Autoimmune diseases can be broadly divided into systemic and organ-specific or localised autoimmune disorders, depending on the principal clinico-pathologic features of each disease. * Systemic autoimmune diseases include SLE, Sjögren’s syndrome, scleroderma, rheumatoid arthritis, and dermatomyositis. These conditions tend to ...
The editor in chief of ”Autoimmunity” is Paolo Casali, the Donald L Bren Professor of Medicine, Molecular Biology & Biochemistry and Director of the ”Institute for Immunology” at the University of California at Irvine.. Adapted from the Wikipedia article Autoimmunity ...
Autoimmunity can thus be defined simply as exceptions to the tolerance “rules.” By doing this, an immune response is generated against self-tissue and cells. These mechanisms are known by many to be intrinsic. However, there are pathogenic mechanisms for the ...Page 1 of 11
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