Rheumatoid - Tumor necrosis factor-alpha – Pharmacology

Rheumatoid

Tumor necrosis factor-alpha – Pharmacology

Tumor necrosis factor promotes the inflammatory response, which, in turn, causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma.

Tumor necrosis factor promotes the inflammatory response, which, in turn, causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma. These disorders are sometimes treated by using a TNF inhibitor. This inhibition can be achieved with a monoclonal antibody such as infliximab (Remicade), adalimumab (Humira) or certolizumab pegol (Cimzia), or with a circulating receptor fusion protein such as etanercept (Enbrel).

==Interactions Tumor necrosis factor-alpha has been shown to interact with TNFRSF1A.

Adapted from the Wikipedia article Tumor necrosis factor-alpha, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki

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