Remitting seronegative symmetrical synovitis with pitting edema (abbreviated RS3PE or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema of the back of the hands and/or feet, and a negative serum rheumatoid factor.
If no underlying disorder can be identified (idiopathic RS3PE), this entity has an excellent prognosis and responds well to treatment.
RS3PE typically involves the joints of the extremities, specifically the metacarpophalangeal and proximal interphalangeal joints, wrists, shoulders, elbows, knees and ankles.
It is more common in older adults, with the mean age between 70 and 80 years in most studies.
It occurs more often in men than in women with a 2:1 ratio.
It is unknown how common this condition occurs.
Adapted from the Wikipedia article Remitting seronegative symmetrical synovitis with pitting edema, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki
Remitting seronegative symmetrical synovitis with pitting edema – Introduction
Remitting seronegative symmetrical synovitis with pitting edema (abbreviated RS3PE or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema of the back of the hands and/or feet, and a negative serum rheumatoid factor.
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