Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function. For instance, ulcerative colitis, Crohn's disease, rheumatoid arthritis, and Multiple Myeloma (MM) sufferers have the condition. It can also be part of a syndrome, for instance in PAPA syndrome. Major and minor trauma are also believed to play a role.
Adapted from the Wikipedia article Pyoderma gangrenosum, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki
Pyoderma gangrenosum – Causes
Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.
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