Mutated citrullinated Vimentin – Introduction

mutated citrullinated vimentin is part of RA diagnostics (rheumatoid arthritis), especially in sera negative for rheumatoid factor (RF negative sera). Anti-MCV antibodies are member of ACPA family, a group of the so called antibodies to citrullinated protein/peptide antigens.

mutated citrullinated vimentin is part of RA diagnostics (rheumatoid arthritis), especially in sera negative for rheumatoid factor (RF negative sera). Anti-MCV antibodies are member of ACPA family, a group of the so called antibodies to citrullinated protein/peptide antigens.

Rheumatoid arthritis is an autoimmune disorder. Detection of specific autoantibodies (antibodies directed against the body’s own tissue) such as rheumatoid factors and ACPAs may provide indication of the disease. In many cases, autoimmune diagnostics are crucial for diagnosing RA correctly and already in the disease’s early stages, when typical symptoms often are lacking but when medical therapy is most effective.


Adapted from the Wikipedia article Mutated citrullinated Vimentin, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki








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