*Chest radiology shows multiple, round, well defined nodules, usually 0.5-2.0& cm in diameter, which may cavitate and resemble tuberculosis.
*Lung function tests may reveal a mixed restrictive and obstructive ventilatory defect with a loss of lung volume. There may also be irreversible airflow limitation and a reduced DLCO.
*Rheumatoid factor, antinuclear antibodies, and non-organ specific antibodies may be present in the serum.
*Silicosis and asbestosis must be considered in the differential with TB.
Adapted from the Wikipedia article Caplan's syndrome, under the G. N. U. Free Documentation License. Please also see http://en.wikipedia.org/wiki
Caplan’s syndrome – Diagnosis
*Chest radiology shows multiple, round, well defined nodules, usually 0.5-2.0& cm in diameter, which may cavitate and resemble tuberculosis. *Lung function tests may reveal a mixed restrictive and obstructive ventilatory defect with a loss of lung volume.
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